Klebsiella pneumoniae is a highly antibiotic-resistant bacterial pathogen known for multiple immune-evasion mechanisms. KivA (Klebsiella immune evasion A) is a recently identified protein that has been shown to enable K. pneumoniae to interfere with host’s IL-17RA signaling pathway. As KivA is newly discovered, very little is known about its function. KivA has been identified to contain a N-terminal SEFIR domain that is suspected to disrupt the crucial interactions between the human SEFIR domains that occur in the IL-17RA pathway. The C-terminal domain has a previously uncharacterized fold with no homology to experimentally solved protein structures. This project aims to express and purify the C-terminal domain by setting up a production and purification protocol. Once pure protein is obtained, domain characterization and crystallization trials will be initiated.